Vir2Drug is a Drug Repurposing web tool that uses network based approaches to identify and rank candidate drugs for a specific pathogen, combining infor-mation obtained from:

•   ranked pathogen-to-pathogen (P2P) networks based on protein similarities between pathogens at host and/or proteome level
•  taxonomy distance between pathogens
•  drugs targeting specific host and/or proteome proteins

Vir2Drug allows the creation of P2P similarity networks based either at host or proteome level, where the edges are scored by means of specific equations depending on whether the pathogen under study is categorised or not. P2P networks are used to screen drugs by means of six available methodologies that account for either the host or pathogen’s protein targets, while the drug ranking is performed by means of seven proposed available equations.

Vir2Drug comes with a frontend web interface that consists of the mainframe and a help page, written in HTML, PHP and JavaScript language environments. The mainframe provides 3 individual steps designed to guide the user until the end of the workflow process. The backend of Vir2Drug has been written in R environment, where several functionalities have been parallelised to achieve fast performance. Evaluation, testing and understanding of Vir2Drug functionalities can be easily performed by means of several available examples provided on the web site.